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The USC vs Notre Dame prediction for this NCAAF showdown on October 18th, 2025 provides key betting insights, including AI-driven picks, betting trends, and best odds. With both teams vying for a critical win, bettors are analyzing the USC vs Notre Dame player props, prizepicks, consensus picks, and public betting trends to find the best value plays.
Preview for USC vs Notre Dame Prediction
This CFB matchup between USC vs Notre Dame is drawing attention from bettors searching for value plays. While sportsbooks may list Notre Dame as the favorite, recent performances suggest this could be a closer contest than expected.
Who is Favored to Win?
Opening Line:
- USC: +275 (BetMGM)
- Notre Dame: -325 (DraftKings)
The USC vs Notre Dame odds positions Notre Dame as a significant favorite, with sportsbooks expecting a high-scoring contest.
Betting History for USC vs Notre Dame
This game has featured high-scoring affairs and strong performances from USC vs Notre Dame.
Moneyline Betting History for USC vs Notre Dame
Below is the moneyline history for the USC vs Notre Dame matchup. The USC Trojans have won 5 out of their last 6 games outright while Notre Dame have won 4 of their last 6 games.
USC Moneyline
History
ND Moneyline
History
Spread Betting History for USC vs Notre Dame
Below is the spread history for the USC vs Notre Dame pick. The USC Trojans have covered the spread in 3 out of their last 6 games while Notre Dame have covered in 3 of the last 6 games.
USC Spread
History
Notre Dame Spread
History
Total Betting History for USC vs Notre Dame
Below is the total history for the USC vs Notre Dame. The total for USC has gone over 4 times of their last 6 games while the total for Notre Dame has gone over for 4 out of the last 6 games.
USC Total
History
Notre Dame Total
History
Consensus Picks & Public Betting Trends for USC vs Notre Dame
Public betting trends provide insight into USC vs Notre Dame consensus picks, helping bettors identify where the sharp and public money is heading.
Moneyline, Spread, and Total Trends for USC vs Notre Dame
Check out the images below for the USC vs Notre Dame public betting trends. Majority of the money is on the Notre Dame for the moneyline and USC for the spread while there is a heavy amount of money on the over.
Moneyline
Trends
Spread
Trends
Over/Under
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SharpMush™ Data for USC vs Notre Dame
SharpMush™ highlights the difference in betting behavior between sharp (high-performing) and mush (low-performing) bettors. It shows where sharp bettors are siding more heavily than bad bettors, helping users identify betting angles with potential value—or traps to avoid.
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SharpMush
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SharpMush
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SharpMush
Prediction for USC vs Notre Dame for NCAAF
Our advanced AI betting algorithms have analyzed the data, trends, and betting splits to bring you the best USC vs Notre Dame pick from our AI sports betting bot.
We have a College Football AI betting bot that give you CFB AI sports predictions for every Saturday.
Today’s AI Sports Pick: USC +9.5
Chip Bayless
A multi-sport specialist who has been known to do it all at the highest level.
45 Day Rankings
Here is where Chip Bayless stands in ranking in comparison to the rest of the Juice Reel betting community.
45 Day Performance
Chip Bayless' record over the past 45 days.
Best Odds for USC vs Notre Dame Bet Predictions
Finding the USC vs Notre Dame best odds ensures bettors maximize value.
Lets take a look at how the best odds compare across the top sportsbooks for each type of bet. There’s no better way to keep track of your bets with our sports betting tracker.
Moneyline
Odds
Spread
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 Over/Under
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Player Props and PrizePicks for USC vs Notre Dame Bet Predictions
Finding the USC vs Notre Dame player prop predictions ensures bettors maximize value. It’s important to take advantage of all that Juice Reel has to offer with our player prop predictions.
Take it to the next level and find College Football player prop predictions for all of our CFB games. Beat the books every Thursday, Friday, and Saturday and tail the hottest players.
Want to win even more? Try out our AI Parlay Generator and double and triple your payday.
Beyond our USC vs Notre Dame AI Predictions and Player Props
Now that you’ve got the best Predictions, Consensus Picks, and Best Odds for the USC vs Notre Dame, would you like more insights to help you bet smarter?
Juice Reel has a multitude of features like discussed in this article to help you win. Download the AI sports betting app for FREE today and lets beat the books together.
